赖绮云,冯锦辉,陈盛强

• 1:广州番禺区中心医院内分泌科
• 2:广州市番禺区石碁人民医院
• 3:广州医学院第二附属医院

摘要(Abstract)：

目的探讨肿瘤坏死因子TNFα-1031T/C基因多态性与Graves病的关系。方法运用多聚酶链反应技术检测60例Graves病及119例正常人肿瘤坏死因子TNFα-1031T/C基因多态性。结果Graves病组肿瘤坏死因子TNFα-1031C/C、T/C、T/T表型频率分别为:0.016 7、0.366 7、0.616 7,对照组分别为0.008 4、0.411 7、0.579 9;Graves病组TNFα-1031 T、TNFα-1031C基因频率分别为:0.800 0、0.200 0,对照组分别为:0.785 7、0.214 3;TNFα-1031 T/C各种基因型频率在Graves病组与正常对照组之间差异无统计学意义(P>0.05)。结论肿瘤坏死因子TNFα-1031 T/C基因多态性与Graves病无明显相关。

关键词(KeyWords)： Graves病;肿瘤坏死因子α-1031T/C;多态性

Abstract:

Keywords:

基金项目(Foundation): 广州市番禺区科技项目:(2009-Z-97-1)

作者(Author): 赖绮云,冯锦辉,陈盛强

DOI: 10.13515/j.cnki.hnjpm.2012.01.034

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