尿中1-羟基芘作为焦炉工多环芳烃暴露生物监测指标的研究Study on Urinary 1-hydroxypyrene concentrations in coke oven workers could be used as biomarker to evalute Polycyclic aromatic hydrocarbon exposure of coke oven workers
王劲,闫卫利,郜舟顺,李如田,王适兴
摘要(Abstract)：
目的探讨焦炉工外暴露等级与尿中1-羟基芘(1-OHPy)浓度的关系。方法以某焦化厂120名生产工人和30名非接触者为研究对象,收集班后6h尿,并收集个人信息,用高效液相法测定尿中1-羟基芘。结果尿中1-羟基芘浓度呈炉顶>炉侧>炉底>对照组的趋势。与外暴露呈显著相关性(r=0.653,P<0.01),同样外暴露条件下,吸烟者尿中1-羟基芘显著高于未吸烟者(P<0.05)。结论焦炉工尿中1-羟基芘水平与外暴露等级存在明显的相关性,可反映多环芳烃暴露个体的内剂量水平。
关键词(KeyWords)： 焦炉工;尿中1-羟基芘;多环芳烃;外暴露等级
基金项目(Foundation):
作者(Author): 王劲,闫卫利,郜舟顺,李如田,王适兴
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