51株血流感染金黄色葡萄球菌科室来源及耐药分析Clinical distribution and drug resistance of staphylococcus aureus in patients with bloodstream infection in a hospital
常富江,张小玲,高歌,高利飞,李振红,付光宇,吕月庆
摘要(Abstract)：
目的分析血流感染患者中分离的金黄色葡萄球菌(staphylococcus aureus,SA)的科室来源及其对临床常用抗菌药物的耐药性,为血流感染患者的辅助诊断及治疗方案提供依据。方法对2017-2019年郑州市人民医院分离到的51株血流感染患者金黄色葡萄球菌用VITEK2-compact全自动细菌鉴定分析仪进行细菌鉴定和药物敏感实验,对实验结果及菌株科室来源进行描述性分析。结果 2017-2019年郑州市人民医院分离到金黄色葡萄球菌的51例血流感染患者,14例(27.45%)来自ICU,6例(11.76%)来自骨科,5例(9.80%)来自呼吸科。51株金黄色葡萄球菌中,48株(94.12%)对青霉素耐药,33株(64.71%)对克林霉素耐药,31株(60.78%)对红霉素耐药,26株(50.98%)对庆大霉素耐药,未检测到对利奈唑胺、万古霉素、奎奴普丁/达福普汀及替加环素耐药菌株。结论血流感染金黄色葡萄球菌在ICU患者中最为常见,其对青霉素、克林霉素和红霉素等多种常见抗生素有较高耐药率,但对利奈唑胺、万古霉素、奎奴普丁/达福普汀及替加环素仍敏感。
关键词(KeyWords)： 血流感染;金黄色葡萄球菌;临床分布;耐药性
基金项目(Foundation):
作者(Author): 常富江,张小玲,高歌,高利飞,李振红,付光宇,吕月庆
DOI: 10.13515/j.cnki.hnjpm.1006-8414.2021.03.008
参考文献(References)：
- [1]毛镭篥,肖盟,王贺,等.全国多中心细菌耐药监测网中血流感染相关金黄色葡萄球菌的分子流行病学研究[J].中国感染与化疗杂志,2015,15(2):120-125.
- [2]Musicha P,Cornick JE,Bar-Zeev N,et al.Trends in antimicrobial resistance in bloodstream infection isolates at a large urban hospital in Malawi(1998-2016):a surveillance study[J].Lancet Infect Dis,2017,17(10):1042-1052.
- [3]Larru B,Gong W,Vendetti N,et al.Bloodstream infections in hospitalized children:epidemiology and antimicrobial susceptibilities[J].Pediatr Infect Dis J,2016,3590(5):507-510.
- [4]张晓艳,崔红,杨爱君,等.新生儿呼吸道合胞病毒下呼吸道感染临床分析[J].中国医刊,2016,51(7):64-67.
- [5]De Rosa FG,Corcione S,Motta I,et al.Risk factors for mortality in patients with Staphylococcus aureus bloodstream infection[J].J Chemother,2016,28(3):187-190.
- [6]Worth LJ,Spelman T,Bull AL,et al.Central line-associated bloodstream infections in Australian intensive care units:Time-trends in infection rates,etiology,and antimicrobial resistance using a comprehensive Victorian surveillance program,2009-2013[J].Am J Infect Control,2015,43(8):848-52.
- [7]Thomer L,Schneewind O,Missiakas D.Pathogenesis of Staphylococcus aureus bloodstream infections[J].Annu Rev Pathol,2016,11:343-364.
- [8]任丽娟.175株金黄色葡萄球菌血流感染的临床分析[J].中国现代医学杂志,2018,28(10):119-122.
- [9]冯锴,李艳.导管相关性血流感染患者金黄色葡萄球菌的耐药情况分析[J].山东医药,2015,55(47):86-87.
- [10]Christopher S,Kovacs MD a,Cynthia Fatica RN,at al.Hospital-acquired Staphylococcus aureus primary bloodstream infection:A comparison of events that do and do not meet the central line associated bloodstream infection defifinition[J].Am J Infect Control,2016,44(11):1252-1255.