N5,10-亚甲基四氢叶酸还原酶基因多态性与颅内动脉瘤的关系The relationship of polymorphism of methylenetetrahydrofolate reductase gene and Intracranial aneurysm
邓维意,孙卫文,戴文伟,许绍强,伍建伟,李明昌,何伟文,陆永健,陈盛强
摘要(Abstract)：
目的探讨同型半胱氨酸和N5,10-亚甲基四氢叶酸还原酶(MTHFR)基因多态性与颅内动脉瘤的关系。方法运用多聚酶链反应技术检测76例颅内动脉瘤及77例正常人MTHFR基因多态性。结果颅内动脉瘤组的MTHFR C677T CT基因型频率较正常对照高(P<0.01),患颅内动脉瘤的风险是对照组的2.57倍,两组等位基因频率差异无统计学意义(P>0.05)。结论 MTHFR CT基因型与颅内动脉瘤明显相关。
关键词(KeyWords)： 同型半胱氨酸;颅内动脉瘤;N5,10-亚甲基四氢叶酸还原酶;多态性
基金项目(Foundation): 广州市卫生科技项目(A2009270)
作者(Author): 邓维意,孙卫文,戴文伟,许绍强,伍建伟,李明昌,何伟文,陆永健,陈盛强
DOI: 10.13515/j.cnki.hnjpm.2011.02.041
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