李琼,李蓬

• 1:平顶山市疾病预防控制中心
• 2:河南省疾病预防控制中心

摘要(Abstract)：

中东呼吸综合征(middle east respiratory syndrome, MERS)是由中东呼吸综合征冠状病毒(MERS coronavirus,MERS-CoV)引起的一种呼吸道疾病,可引发多种严重的并发症,病死率高,对全球公共卫生造成了严重威胁。该病自2012年首次报告以来,截至2018年9月底,全球共报告了2 260例经实验室确认的MERS-CoV感染病例,其中死亡病例803例,病死率为35.5%。本文从MERS的病原学、流行病学、临床表现、实验室诊断及预防与控制等方面进行了阐述,以期为预防和控制该病提供参考。

关键词(KeyWords)： 中东呼吸综合征;冠状病毒;冠状病毒实验室检测

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李琼,李蓬

DOI: 10.13515/j.cnki.hnjpm.1006-8414.2020.02.001

参考文献(References)：

• [1] Zaki A M, Van B S, Bestebroer T M, et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia[J].New England Journal of Medicine, 2012, 367(19):1814.
• [2] Cotten M, Watson S J, Kellam P, et al. Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia:a descriptive genomic study[J].Lancet, 2013, 382(9909):1993-2002.
• [3] Cotten M, Watson S J, Zumla A I, et al. Spread, circulation,and evolution of the Middle East respiratory syndrome coronavirus.[J].Mbio, 2014, 5(1):245-256.
• [4] Corman V M, Ithete N L, Richards L R, et al. Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat[J]. Journal of Virology, 2014, 88(19):11297.
• [5] World Health Organization.Middle East respiratory syndrome coronavirus(MERS-Co V)[DB/OL].(http://www.emro.who.int/health-topics/mers-cov/situation-update.html).
• [6] Drosten C, Kellam P,Memish Z A.Evidence for Camel-to-Human Transmission ofMERS Coronavirus[J].NewEngland Journal ofMedicine, 2014, 371(14):1359-60.
• [7] Meyer B, Müller M A, Corman V M,et al. Antibodies against MERS coronavirus in dromedary camels, United Arab Emirates, 2003 and 2013[J].Emerging Infectious Diseases, 2014,20(4):552.
• [8] Nowotny N, Kolodziejek J. Middle East respiratory syndrome coronavirus(MERS-Co V)in dromedary camels, Oman, 2013[J]. Euro Surveill, 2014, 19(16):20781.
• [9] Raj VS, Farag EA, Reusken CBEM, et al. Isolation of MERS Coronavirus from a Dromedary Camel, Qatar, 2014[J].Emerging Infectious Diseases, 2014, 20(8):1339.
• [10] Oboho I K,Tomczyk S M,Alasmari A M,et al.2014MERS-Co V outbreak in Jeddah-a link to health care facilities[J].N Engl J Med, 2015, 372(9):846-854.
• [11] Ki M. 2015 MERS outbreak in Korea:hospital-to-hospital transmission[J].Epidemiology&Health, 2015, 37.
• [12] Centers for disease control and prevention. MERS Clinical Features[DB/OL].(https://www. cdc. gov/coronavirus/mers/clinical-features. html)
• [13] World Health Organization. Laboratory Testing for Middle East Respiratory Syndrome Coronavirus Interim guidance(revised)[S].January 2018.
• [14] Raj V S, Mou H, Smits S L, et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC[J]. Nature, 2013, 495(7440):251-254.
• [15] Widagdo W et al. Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels[J].J Virol, 2016, 90(9):4838-4842.
• [16] Assiri A, Altawfiq J A, Alrabeeah A A, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia:a descriptive study[J].Lancet Infectious Diseases, 2013, 13(9):752-761.
• [17] Corman V M, Eckerle I, Bleicker T, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction[J].Euro Surveill, 2012, 17(39):3-8.
• [18] Corman V M, Müller M A, Costabel U, et al. As says for laboratory confirmation of novel human coron avirus(hCoV-EMC)infections[J].2012, 17(49):2-10.
• [19] Lu X,Whitaker B,Sakthivel S K,et al.Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus[J].Journal of Clinical Microbiology,2014, 52(1):67-75.
• [20] Drosten C, Meyer B, Müller M A, et al. Transmis sion of MERS-coronavirus in household contacts[J].New England Journal of Medicine, 2014, 371(9):828-35.
• [21] Reusken C, Mou H, Godeke G J, et al. Specific serology for emerging human coronaviruses by protein microarray[J].2013, 18(14):20441.
• [22] Trivedi S, Miao C, Alabdallat M M, et al. Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-Co V infection[J].Journal of Medical Virology, 2017, 90(2):547.
• [23] Choe P et al. MERS-Co V antibody responses 1 year after symptom onset, South Korea, 2015[J]. Emerg Infect Dis, 2017, 23(7):1079-1084.
• [24] World Health Organization. Middle East respiratory syndrome coronavirus(MERS-Co V)[DB/OL].(http://www.who.int/news-room/fact-sheets/detail/middle-east-respiratory-syndrome-coronavirus-(mers-cov).
• [25] Arabi Y M, Balkhy H H, Hayden F G, et al. Middle East Respiratory Syndrome[J].New England Journal of Medicine,2017, 376(6):584.
• [26] Centers for disease control and prevention. Interim Infection Prevention and Control Recommendations for Hospitalized Patients with Middle East Respiratory Syndrome Coronavirus(MERS-Co V)[DB/OL].(https://www. cdc.gov/coronavirus/mers/infection-prevention-control. html).